We improve signal detection in clinical trials

Tiny "nanodiscs" composed of layers of lipids surrounded by a belt represent a very powerful platform to study intermediates formed in the process of protein aggregation. http://bit.ly/2iZ7xTc

ALZFORUM recaps CTAD: "... the field’s main thrust clearly was on how to apply a new understanding of the pre-dementia stages of AD toward running better therapeutic trials."  http://bit.ly/2BkxfJt

“Making an AD mouse model that incorporates both Aβ and tau pathologies in a more AD-relevant context has been greatly sought after but difficult to accomplish,” said senior author Virginia M-Y Lee, PhD, director of the Center for Neurodegenerative Disease Research at U. of Pennsylvania. http://bit.ly/2As5jCd

“The Virgil software and tablet is pretty amazing. It’s the most user/site friendly we have used for clinical trials and we have used several. "                                                                                           - Principal Investigator https://lnkd.in/dYwff6e

U of Illinois researchers use tiny pulses of lightwave spectrum to control how neurons fire in mouse brains.  http://bit.ly/2i3ePRS

New research from India: a fluorescent gold nanocluster able to cross the blood–brain barrier may  be used to carry drugs to the brain for imaging.  http://bit.ly/2Bngnh0

Can health care databases be used to confirm a supplemental indication that has been demonstrated in a randomized clinical trial for an approved medication? http://bit.ly/2mU3Yix

"Machine learning can combine the intuitive flexibility of a clinician with the formality of the statistics that drive evidence-based medicine. Models that pull together thousands of variables can still be rigorous and mathematically sound." says Dr. Parashkev Nachev, University College  London Institute of Neurology.  https://lnkd.in/eqhYbGg

Bill Gates cites need for better data applications and easier clinical trial enrollment in announcing a personal investment of $50 million in the Dementia Discovery Fund. http://bit.ly/2zzWDJS

Global Alzheimer’s Platform (GAP) Foundation model promises to accelerate clinical trials and increase patient participation in Alzheimer’s clinical research. http://bit.ly/2iS4MPG

Solutions for Sponsors and Contract Research Organizations (CROs)

We help sponsors and CROs improve reliability in clinical trials.

Virgil Platform

Use our eSource platform to maximize data quality, standardize assessments and improve signal detection.

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Independent Ratings

Our expert, calibrated raters remotely administer live assessments of subjects at sites to maximize study power and minimize bias and variability.

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Independent Review

Our global cohort of expert clinicians review assessment data and recordings to flag potential discrepancies and surface quality issues.

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Rater Qualification and Certification

Our clinical experts tailor training and certification via options ranging from face-to-face to totally virtual.

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Clinical Data Analytics

Our statisticians and clinical scientists help build data quality metrics that provide insight into how a study’s data are progressing.

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Solutions for Sites

Data capture happens every day at clinical trial sites. That’s why we rely on input from hundreds of raters, site coordinators, and PIs in evolving Virgil.

Virgil Tablet

Reduces administrative burden for clinicians and study coordinators.

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Virgil Portal

Enables raters, study coordinators and PIs to securely access the exact data each needs to streamline reviews, approvals and query resolution.

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Rater Training

Qualify for participation in studies with tailored, engaging and conveniently delivered training programs.

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What We Believe

MedAvante-ProPhase exists to help unlock new and better treatments through smarter, faster clinical trials.

We believe data will transform the way the world understands health and medicine, greatly improving the way potential treatments are tested.

Our mission is to apply deep scientific expertise to optimizing the quality of clinical trial outcome data. We will do this with cohesive, interoperable software and accurate, precise clinician services that work together to improve the collection, management and analysis of clinical study data.

Why MedAvante-ProPhase?

To improve the ability to detect a signal of efficacy in a clinical trial and reduce the risk of inconclusive results, drug developers, study teams and research clinicians need a capable and trusted global partner.

MedAvante-ProPhase is a clinical data sciences company providing science-driven, technology-enabled clinical measurement and signal detection solutions with a history of proven innovation.

Our clinical expertise and record of combining scientific innovation with digital capabilities is rooted in years of experience working with some of the most challenging of clinical trial outcomes – Central Nervous System (CNS) disorders.

The Virgil Investigative Study Platform, paired with our suite of clinician services, make MedAvante-ProPhase the most proficient and reliable global partner for improved signal detection and smarter, faster clinical trials.

Why Virgil?

Virgil was created by clinicians, for clinicians. Virgil addresses the real needs of raters and coordinators, and reduces process complexity and administrative burden for sites.

Virgil enables the full complement of electronic clinical outcome assessments (eCOA) including:

• Clinician-Reported Outcomes (eClinRO)

• Observer-Reported Outcomes (eObsRO)

• Patient-Reported Outcomes (ePRO)

Explore the Virgil Platform

Virgil amplifies the power of MedAvante-ProPhase clinician services as the digital platform delivering Independent Ratings and Independent Review with the same timely results and data quality, eliminating paper and increasing strategic options for a smarter trial.

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"The Virgil software and tablet is pretty amazing. It’s the most user/site friendly we have used for clinical trials and we have used several. The software mimics writing on paper extremely well, and we appreciate that there wasn’t any skimping in the processor speed. The Virgil tablet has gained some big fans at our site."

— Principal Investigator, USA

"The industry is hungry for innovation. And they’re hungry for innovation because the current models are struggling."

— Senior executive, large pharma

"Our team finds the tablets operating on the Virgil system very user-friendly very easy to get used to and really straight forward to work with. It is fast and properly responsive to our inputs, stylus use is similar to using a normal pen and paper set-up. All in all, the Virgil system is our favourite system to work with!"

— Principal Investigator, EU

"Losing patient data can be tragic. I look very carefully at data loss rates because I want them to be 0.01% or 0%. I cannot afford to lose data. The loss rates are a way that I differentiate one provider from another."

— Senior executive, biotech

"The Virgil tablet and its well-designed digital scales improve our ability to administer quality assessment by being easy-to-use and helpful to our raters. We like the way recordings are collected and appreciate the convenience of handling them with no additional steps for our team to perform… We have had a very good experience with the Virgil platform and we recommend its use to any clinical trial sponsor."

— Principal Investigator, USA

Our approach

We design with a clinician’s brain and a startup’s heart. Created by clinicians for clinicians, Virgil provides built-in clinical guidance to help standardize assessments and increase the quality of trial results.

How we help

We provide clinicians and researchers with the tools, data-driven insights, and guidance they need to get their work done more easily and efficiently.

Our services, technologies, and clinical guidance help bring drug therapies to market with smarter, faster, more adaptive clinical trials.

6000+ hours of R&D

2M+ pages

MedAvante, for clinicians by clinicians.

How we help

We provide clinicians and researchers the tools, data-driven insights and guidance they need to get their work done more easily and efficiently.

Get a Virgil Demo

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Since 2005

MedAvante, for clinicians by clinicians